Abstract:

At present，conization is the main treatment for cervical high ⁃ grade squamous intraepithelial neoplasia（HSIL）. Women treated for HSIL had a higher risk of developing cervical cancer than the general popula⁃ tion. Women with persistent high⁃risk human papillomavirus（HR⁃HPV）infection after treatment have an increased risk of disease recurrence，which can progress to cervical cancer. Factors related to the persistence of HR⁃HPV af⁃ ter conization for HSIL included patients' HPV subtype，preoperative HPV load，multiple infections，type of con⁃ ization，age and menopausal status，lesion grade，resection margin status and vaginal microecology etc.，though their relations with the persistent HR⁃HPV remain controversial. Determining risks of persistent HR⁃HPV infection after cervical excision is useful for identifying women at a higher risk of disease recurrence. Thus，this paper， based on relevant domestic and foreign researches，discusses the risk factors of persistent HR⁃HPV infection after conization for HSIL.

Key words:

"> cervical intraepithelial neoplasia； conization； human papillomavirus； persistent HPV infection； risk factors